Tirzepatide vs Semaglutide

Based on current research, tirzepatide and semaglutide are commonly used as type 2 diabetes drugs for weight management. While tirzepatide may potentially be more effective, it is still too early to draw definitive conclusions.

Is tirzepatide better than semaglutide?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It mimics the GLP-1 hormone and reduces hunger, while also releasing fullness signals to the brain during digestion.

Tirzepatide, sold as Mounjaro, acts as a glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. It mimics both the GLP-1 and GIP hormones, which promote insulin production and induce feelings of fullness.

Do they both work for weight loss?

Some recent studies have compared semaglutide and tirzepatide for weight loss. However, there are some important caveats to note about these studies:

The doses of semaglutide and tirzepatide given to participants were not equal. The higher dose of tirzepatide may have influenced the results. It is possible that if the dose of semaglutide had been comparable, weight loss might have increased.
These studies only examined the weight loss effects in people with type 2 diabetes. It is possible that individuals without diabetes may not experience the same effects.
However, studies suggest that semaglutide may be an effective weight loss treatment for individuals without diabetes.

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Sep 19, 2023 Mr. Panda

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